브로만탄 Bromantane (Ladasten) 50mg 캡슐, 90개입

브로만탄 Bromantane (Ladasten) 50mg 캡슐, 90개입

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WHAT IS  BROMANTANE?

Bromantane is 2-bromophenyl-1-amino adamantane. The drug belongs to the group of adamantanes, such as amantadine, memantine, and molecules known only in Russia (kemantane, adopronin, gludantane, midantane).

During the 1996 Olympic Games in Atlanta, USA, a doping substance little known in the West, bromantane, made its appearance. Five athletes (four Russians and one Lithuanian) who tested positive were disqualified by the International Olympic Committee. This decision was appealed to the athletics arbitration tribunal which canceled the disqualifications. Since then, the product has been added to the list of doping agents. During the ski championships at Trondheim, Norway in February 1997, a Russian athlete was disqualified because his urine tested positive. The drug is prescribed for Russian cosmonauts as an immune stimulant. Its probable use by Russian soldiers in Afghanistan, and more recently Chechnya, is related to its psychostimulating effect.

BROMANTANE BENEFITS

Bromantane is very different from typical psychostimulants in that it does not work on any particular receptor in the brain but acts on the expression of 1116 genes, all of which affect the central nervous system. Its unique mild psychostimulating effect can be attributed particularly to an increase in the expression of tyrosine hydroxylase – the key ferment responsible for dopamine synthesis. In other words, bromantane indirectly stimulates the expression of dopamine, unlike typical stimulants, which simply release dopamine already stored in the synaptic cleft. As a result, Ladasten has a weaker stimulating effect and does not cause dopamine depletion.

Bromantane was also found to have an anxiolytic effect that was attributed to a decrease in the expression of GABA-transporter gene. This results in an increase in GABA in the synaptic cleft, which explains its anxiolytic properties. This compound was extensively studied in Russia and was found to be very safe.

Bromantane can be used by those who have the following symptoms:

  • Asthenic disorders of different types, e.g. somatic symptoms disorders and after-effects of infections
  • Neurasthenia (exhaustion of the central nervous system’s energy reserves).

BROMANTANE DOSAGE

50-200mg per day

RESEARCH

  • The neuro- and psychophysiological effects of bromantane https://www.ncbi.nlm.nih.gov/pubmed/10998997
  • Correlated interconnection between pharmacokinetic and dynamic development of the pharmacokinetic effects of bromontan. Biull Eksperiment Biolog Med. 1995; 119: 305-308
  • A quantitative pharmaco-electrocephalographic analysis of the action of bromontan. Biull Eksperiment Biolog Med. 1993; 116: 515-518
  • Experimental rationale for use of drugs to increase the reistance of human body to the combined action of monoxide and hyperthermia. Meditsin Truda Promyshl Ekolog. 1993; 9–10: 10-11